What Is MEDVi QUAD?
Erectile dysfunction affects roughly 1 in 3 men over 40, and the treatment landscape has expanded well beyond a single-ingredient pill. MEDVi QUAD is a clinician-prescribed compounded medication that combines four complementary ingredients, PT-141, Sildenafil, L-Citrulline, and Tadalafil, into a single sublingual (under-the-tongue) liquid dose. It holds our #1 spot, driven largely by its flexible dose-pack pricing and consistently high user ratings (9.7/10, 21,094 votes).
10-15 min
Onset time
36 hrs
Response window
$114/mo
Starting price
4-in-1
Active compounds
MEDVi QUAD at a Glance
| Product Type | Prescription-only compounded medication |
|---|---|
| Delivery Method | Sublingual liquid (under the tongue) |
| Active Ingredients | PT-141, Sildenafil, L-Citrulline, Tadalafil |
| Onset Time | As little as 10-15 minutes (individual results vary) |
| Response Window | Up to 36 hours (requires sexual stimulation) |
| Pricing | $114/mo (5 doses) or $179/mo (10 doses) |
| What's Included | Consultation, prescription, medication, discreet shipping |
| No-Approval Policy | No charge if clinician does not approve the prescription |
The Four Active Ingredients
Each ingredient in MEDVi QUAD targets a different part of the sexual response cycle, something no single-ingredient pill can achieve.
PT-141, Ignites Desire
PT-141 (bremelanotide) works through melanocortin receptors in the central nervous system to support the neurological and psychological side of arousal, addressing desire and mental readiness rather than just physical blood flow.
L-Citrulline, Rapid Flow
An amino acid that boosts nitric oxide production to relax blood vessels and support stronger, faster blood flow.
Sildenafil, Erection Firmness
The most widely recognized ED ingredient, enhancing blood flow to support erection quality and firmness. According to the FDA, sildenafil is approved for the treatment of erectile dysfunction in adult men.
Tadalafil, Extended Duration
Best known for its long active window, up to 36 hours, removing the pressure of strict timing.
Why Sublingual Delivery Matters
Standard ED tablets are swallowed and absorbed through the gut, a process that takes time and can be slowed by food. Sublingual delivery bypasses digestion, the active compounds pass directly into the bloodstream through the mucous membranes under the tongue.
| Feature | MEDVi QUAD (Sublingual) | Standard Oral Tablets |
|---|---|---|
| Onset time | 10-15 minutes | 30-60+ minutes |
| Food interaction | Minimal | Can delay or reduce absorption |
| Active ingredients | 4 compounds in 1 dose | Typically 1 per pill |
| Duration window | Up to 36 hours | Varies (4-36 hrs depending on drug) |
Pricing & Dose Flexibility
MEDVi QUAD is offered as a monthly subscription in two plans: $114/month for 5 doses (about $22.80/dose) or $179/month for 10 doses (about $17.90/dose). Both plans cover the consultation, the compounded medication, free rush shipping, and ongoing clinical support, and the dose-count choice rewards men who know they will want more frequent doses without changing subscription tiers.
Pros & Cons
Pros
- Four-mechanism formula instead of a single ingredient
- Sublingual delivery for faster, more consistent onset
- Up to 36-hour response window
- Choice of 5- or 10-dose monthly packs
- Clinician-reviewed and medically supervised
- No charge if not approved
Cons
- Requires a prescription and medical approval
- Higher monthly cost than generic single-ingredient options
- Not suitable for all health profiles
- Compounded medication, not individually FDA-approved
Who Should Consider MEDVi QUAD?
MEDVi QUAD may be a good fit for men who have tried standard single-ingredient ED medications and found results inconsistent, or who want to size their monthly dose count to their actual usage. It is likely not the best starting point for someone who has never tried ED medication before, where a lower-cost generic is a reasonable first step.
Safety, Side Effects & Medical Oversight
MEDVi QUAD is only dispensed after a licensed clinician reviews your intake. It is not appropriate for everyone.
How MEDVi QUAD Compares
MEDVi QUAD sits at nearly identical pricing to FeelGood QUAD, our #2-ranked provider, though the formulas differ, FeelGood QUAD leans on Apomorphine and Vardenafil, while MEDVi QUAD uses the PT-141 desire peptide and an L-Citrulline blood-flow booster. Against BetterMe Rx QMAX, MEDVi does not currently run a promotional discount, but it does publish its full pricing up front for both dose-pack sizes, while QMAX confirms pricing only after intake.
| Feature | MEDVi QUAD | FeelGood QUAD | BetterMe Rx QMAX |
|---|---|---|---|
| Formula | 4-in-1 sublingual liquid | 4-in-1 sublingual liquid | 4-in-1 sublingual liquid |
| Onset | 10-15 min | ~10 min | ~10 min |
| Duration | Up to 36 hrs | Up to 36 hrs | Up to 36 hrs |
| Starting price | $114/mo (5 doses) | $114/mo (5-pack) | 50% off today summer special |
Frequently Asked Questions
No. MEDVi QUAD is a prescription-only compounded medication that requires clinician approval. It is not sold over the counter and should not be confused with herbal ED supplements.
Because it is absorbed sublingually rather than swallowed, many users report effects within 10-15 minutes. This is faster than most standard oral ED tablets, though individual timing varies.
No. MEDVi QUAD creates a response window, an erection still requires natural sexual stimulation during that window. It does not cause automatic or prolonged erections.
If a licensed U.S. clinician reviews your intake and determines MEDVi QUAD is not appropriate for your health profile, no charge is applied.
MEDVi QUAD is a compounded medication and is generally not covered by standard insurance plans. Pricing is $114/month for 5 doses or $179/month for 10 doses, including consultation, prescription, medication, and shipping.
Viagra (sildenafil) and Cialis (tadalafil) are single-ingredient PDE5 inhibitors taken orally. MEDVi QUAD combines both, plus PT-141 for desire and L-Citrulline for blood flow, in one sublingual dose designed to work faster and cover a broader range of the sexual response cycle.
Our Verdict: MEDVi QUAD
Editorial Verdict
MEDVi QUAD is a thoughtfully designed, clinician-managed ED treatment that takes a broader approach than conventional single-ingredient pills. Its dose-pack flexibility, choosing between 5 and 10 doses a month, is a genuine differentiator among the 4-in-1 formulas we track, and its 21,094 user votes make it the most validated option on this list.
It is not a cure-all, and it costs more than generic alternatives. But for men who have hit the ceiling of what standard tablets can offer, it is a legitimate option worth exploring under medical supervision.